Hyperinsulinism

HyperinsulinismHYPERINSULINISM (hypoglycemic disease) - a disease characterized by attacks of hypoglycemia caused by an absolute or relative increase insulin levels. Etiology, pathogenesis. Tumor of the islets of Langerhans (insulinoma), diffuse hyperplasia of beta cells of the pancreas, diseases of the Central nervous system, liver, Unibank-eroticheskie tumors secreting insulin-like substances, swelling (usually of connective tissue of origin), strongly absorbing glucose, insufficient products contentware hormones. Hypoglycemia leads to disruption of the functional state of the CNS, increased activity of the sympathetic-adrenal system. The symptoms for. Ill aged 26-55 years, more often than women. Episodes of hypoglycemia occur usually in the morning on an empty stomach, after a long starvation; and functional hyperinsulinism - after ingestion of carbohydrates. Physical workload, mental experiences can be provoking points. Women first attacks may be repeated only in the premenstrual period. The beginning of an attack is characterized by a feeling of hunger, sweating, weakness, limb tremor, tachycardia, anxiety, pallor, diplopia, paresthesia, mental stimulation, unmotivated behavior, disorientation, dysarthria (slurred speech); in come further loss of consciousness, clinical and tonic convulsions, sometimes resembling epileptic seizures, coma Gelateria and hyporeflexia. Sometimes the attacks begin with a sudden loss of consciousness. In the interictal period symptoms caused by damage to the Central nervous system: memory loss, emotional instability, indifference to surroundings, loss of professional skills, sensory impairment, paresthesia, symptoms pyramidal insufficiency, abnormal reflexes. Because of the need for frequent meals, patients are overweight. For the diagnosis of conduct defining the level of sugar in the blood, immunoreactive insulin and C-peptide (fasting and background samples with fasting and glucose tolerance test). For topical diagnosis using angiography of the pancreas, ultrasound, computed tomography, the retrograde pancreatoduodenectomy. Treatment of insulinoma and tumors of other organs, contributing to the development of hypoglycemic events, surgical. Functional hyperinsulinism assign a fractional power with restriction of carbohydrates, corticosteroids (prednisone at 5-15 mg/day). Bouts of hypoglycemia cropped intravenous 40-GO ml of 40% glucose solution..



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